WWAWXGQN
type: UserItem
resource: Elevated high-sensitivity troponin T levels are associated with adverse cardiac remodelling and myocardial fibrosis in hypertrophic cardiomyopathy
tagged: UserTag
  label: Adolescent
tagged: UserTag
  label: Adult
tagged: UserTag
  label: Aged
tagged: UserTag
  label: Atrial Remodeling
tagged: UserTag
  label: Cardiomyopathy, Hypertrophic/*blood
tagged: UserTag
  label: Cohort Studies
tagged: UserTag
  label: Echocardiography
tagged: UserTag
  label: Electrocardiography
tagged: UserTag
  label: Exercise Test
tagged: UserTag
  label: Female
tagged: UserTag
  label: Fibrosis/blood
tagged: UserTag
  label: Humans
tagged: UserTag
  label: Magnetic Resonance Imaging
tagged: UserTag
  label: Male
tagged: UserTag
  label: Middle Aged
tagged: UserTag
  label: Myocardium/*pathology
tagged: UserTag
  label: Organ Size
tagged: UserTag
  label: Prognosis
tagged: UserTag
  label: Retrospective Studies
tagged: UserTag
  label: Risk Assessment
tagged: UserTag
  label: Severity of Illness Index
tagged: UserTag
  label: Tertiary Care Centers
tagged: UserTag
  label: Troponin T/*blood
tagged: UserTag
  label: Ventricular Remodeling
tagged: UserTag
  label: Young Adult

Elevated high-sensitivity troponin T levels are associated with adverse cardiac remodelling and myocardial fibrosis in hypertrophic cardiomyopathy
type: AcademicArticle
abstract: INTRODUCTION: Clinical manifestations of hypertrophic cardiomyopathy (HCM) range from asymptomatic disease to early-onset heart failure and sudden cardiac death (SCD). Risk stratification for SCD remains imperfect and novel risk markers are needed. The aim of our study was to evaluate the association of elevated high-sensitivity cardiac troponin T levels (hs-cTnT) with the severity of disease expression and adverse events in patients with HCM. METHODS: All patients followed-up at a dedicated HCM clinic at a tertiary care centre between April 2012 and March 2014 were analysed. The clinical care track for these patients includes 12-lead ECG, blood work-up, echocardiography, Holter ECG, exercise stress testing and cardiovascular magnetic resonance imaging (CMR). Clinical data were obtained from medical records. RESULTS: Of 91 HCM patients (77% males, mean age at follow up 51 +/- 16 years), 46 (51%) had elevated hs-cTnT levels (>0.014 ng/ml). Patients with elevated hs-cTnT levels had greater maximum wall thickness (23 +/- 7 mm vs 19 +/- 3 mm, p = 0.001), more often had myocardial fibrosis (96% vs 54%, p <0.001), and lower exercise capacity (90% predicted vs 76% predicted, p = 0.002). There was a trend towards lower event-free survival estimates (Kaplan-Meier method, 15% vs 7%, p = 0.16). CONCLUSIONS: Elevated hs-cTnT levels in HCM patients are associated with disease severity and, potentially, with more adverse cardiac events. Future studies should test whether integration of hs-cTnT in clinical decision algorithms will improve risk stratification.
pages: w14285
doi: 10.4414/smw.2016.14285
source: 26999566
creator: Person
author list: Person
is part of: Issue
  date: 2016-03-22
  volume: 146
  is part of: Swiss Med Wkly
    type: Journal
    issn: 1424-3997 (Electronic) 0036-7672 (Linking)

Person
given name: S.
surname: Hasler

Person
given name: R.
surname: Manka

Person
given name: M.
surname: Greutmann

Person
given name: O.
surname: Gamperli

Person
given name: C.
surname: Schmied

Person
given name: F. C.
surname: Tanner

Person
given name: P.
surname: Biaggi

Person
given name: T. F.
surname: Luscher

Person
given name: D. I.
surname: Keller

Person
given name: C.
surname: Gruner