U3TSISTG
type: UserItem
resource: Impact of allogeneic blood transfusions on clinical outcomes in severely burned patients
tagged: UserTag
  label: *Hospital Mortality
tagged: UserTag
  label: Adult
tagged: UserTag
  label: Anemia/*therapy
tagged: UserTag
  label: Blood Transfusion/*statistics & numerical data
tagged: UserTag
  label: Blood products
tagged: UserTag
  label: Body Surface Area
tagged: UserTag
  label: Burn
tagged: UserTag
  label: Burns/pathology/*surgery
tagged: UserTag
  label: Catheter-Related Infections/epidemiology
tagged: UserTag
  label: Central Venous Catheters
tagged: UserTag
  label: Erythrocyte Transfusion/statistics & numerical data
tagged: UserTag
  label: Female
tagged: UserTag
  label: Humans
tagged: UserTag
  label: Infections
tagged: UserTag
  label: Infections/*epidemiology
tagged: UserTag
  label: Intensive Care Units
tagged: UserTag
  label: Length of Stay/*statistics & numerical data
tagged: UserTag
  label: Male
tagged: UserTag
  label: Middle Aged
tagged: UserTag
  label: Morbidity
tagged: UserTag
  label: Mortality
tagged: UserTag
  label: Plasma
tagged: UserTag
  label: Platelet Transfusion/statistics & numerical data
tagged: UserTag
  label: Pneumonia/epidemiology
tagged: UserTag
  label: Sepsis/epidemiology
tagged: UserTag
  label: Systemic Inflammatory Response Syndrome/*epidemiology
tagged: UserTag
  label: Thromboembolic events
tagged: UserTag
  label: Thrombosis/*epidemiology
tagged: UserTag
  label: Transfusion Reaction
tagged: UserTag
  label: Transplantation, Homologous
tagged: UserTag
  label: Wound Infection/epidemiology

Impact of allogeneic blood transfusions on clinical outcomes in severely burned patients
type: AcademicArticle
abstract: BACKGROUND: Allogeneic blood transfusions are common in the treatment of severely burned patients as surgery may lead to major blood loss. However, transfusions are associated with a number of adverse events. Therefore, the purpose of our study was to investigate the impact of allogeneic blood transfusions on clinical outcomes in severely burned patients. METHODS: This retrospective study included all adult patients admitted to the burn center of the University Hospital Zurich between January 2004 and December 2014, with burn injuries greater than 10% of total body surface area and receiving both surgical and intensive care treatment. Primary Endpoints were infectious or thromboembolic complications and mortality and secondary endpoints were length of hospital and ICU stay. Simple and multivariable logistic and linear regression models, adjusted for injury severity and confounders, were applied. RESULTS: 413 patients met inclusion criteria of which 212 patients (51%) received allogenic blood products. After adjustment for injury severity and confounders, red blood cell transfusion was independently associated with wound infection (OR 13.5, 95% CI 1.7-107, p = 0.014), sepsis (OR 8.3, 4.2-16.3; p < 0.001), pneumonia (OR 4.7, 2.2-10.0; p < 0.001), thrombosis (OR 3.0, 1.2-7.4; p = 0.015), central line infection (OR 34.7, 4.6-260; p = 0.001) and a longer ICU and hospital stay (difference 17.7, CI 12.1-23.4, p < 0.001 and 22.0, 15.8-28.2, p < 0.001, respectively). Fresh frozen plasma transfusion was independently associated with a longer ICU and hospital stay (difference 13.7, 95% CI 5.5-21.8, p = 0.001 and 13.5, 4.6-22.5, p = 0.003, respectively). Platelet transfusion was independently associated with systemic inflammatory response syndrome (OR 4.5, 1.3-15.5; p = 0.018) and mortality (OR 5.8, 2.1-16.0; p = 0.001). CONCLUSION: Transfusion of allogeneic blood products is associated with an increased infection rate and thromboembolic morbidity and a longer hospital stay in …
pages: 1083-1090
doi: 10.1016/j.burns.2019.11.005
source: 31866181
creator: Person
author list: Person
is part of: Issue
  date: 2019-12-24
  volume: 46
  issue: 5
  is part of: Burns
    type: Journal
    issn: 1879-1409 (Electronic) 0305-4179 (Linking)

Person
given name: A.
surname: Kaserer

Person
given name: J.
surname: Rossler

Person
given name: K.
surname: Slankamenac

Person
given name: M.
surname: Arvanitakis

Person
given name: D. R.
surname: Spahn

Person
given name: P.
surname: Giovanoli

Person
given name: P.
surname: Steiger

Person
given name: J. A.
surname: Plock