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type: UserItem
resource: Age is not associated with intracranial haemorrhage in patients with mild traumatic brain injury and oral anticoagulation
tagged: UserTag
  label: Administration, Oral
tagged: UserTag
  label: Age
tagged: UserTag
  label: Age Factors
tagged: UserTag
  label: Aged
tagged: UserTag
  label: Anticoagulants/*administration & dosage/*therapeutic use
tagged: UserTag
  label: Anticoagulation
tagged: UserTag
  label: Brain Injuries, Traumatic/*complications/*drug therapy
tagged: UserTag
  label: Female
tagged: UserTag
  label: Humans
tagged: UserTag
  label: Intracranial Hemorrhages/*complications/*drug therapy
tagged: UserTag
  label: Male
tagged: UserTag
  label: Mild traumatic brain injury
tagged: UserTag
  label: Risk factor

Age is not associated with intracranial haemorrhage in patients with mild traumatic brain injury and oral anticoagulation
type: AcademicArticle
abstract: BACKGROUND: Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores or recommendations exist for the management of mild traumatic brain injury in these patients. We therefore tested whether age as one of the high risk factors of the Canadian head CT rule is applicable to a patient population on oral anticoagulants. METHODS: This cross-sectional analysis included all patients with mild TBI and concomitant oral anticoagulant therapy admitted to the Emergency Department, Inselspital Bern, Switzerland, from November 2009 to October 2014 (n = 200). Using a logistic regression model, two groups of patients with mild TBI on oral anticoagulant therapy were compared - those with and those without intracranial haemorrhage. RESULTS: There was no significant difference in age between the patient groups with (n = 86) and without (n = 114) intracranial haemorrhage (p = 0.078). In univariate logistic regression, GCS (OR = 0.419 (0.258; 0.680)) and thromboembolic event as reason for anticoagulant therapy (OR = 0.486 (0.257; 0.918)) were significantly associated with intracranial haemorrhage in patients with mild TBI and anticoagulation (all p < 0.05). However, there was no association with age (p = 0.078, OR = 1.024 (0.997; 1.051)), the type of accident or additional medication with acetylsalicylic acid or clopidogrel ((both p > 0.05; 0.552 (0.139; 2.202) and 0.256 (0.029; 2.237), respectively). CONCLUSION: Our study found no association between age and intracranial bleeding. Therefore, until further risk factors are identified, diagnostic imaging with CCT remains necessary for mild TBI patients on oral anticoagulation of all ages, especially those with therapeutic anticoagulation because of thromboembolic events.
pages: 12
doi: 10.1186/s12952-016-0055-y
source: 27401915
creator: Person
author list: Person
is part of: Issue
  date: 2016-07-13
  volume: 15
  issue: 1
  is part of: J Negat Results Biomed
    type: Journal
    issn: 1477-5751 (Electronic) 1477-5751 (Linking)

Person
given name: T. C.
surname: Sauter

Person
given name: S.
surname: Ziegenhorn

Person
given name: S. S.
surname: Ahmad

Person
given name: W. E.
surname: Hautz

Person
given name: M. E.
surname: Ricklin

Person
given name: A. B.
surname: Leichtle

Person
given name: G. M.
surname: Fiedler

Person
given name: D. G.
surname: Haider

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given name: A. K.
surname: Exadaktylos