Echocardiography does not predict mortality in hemodynamically stable elderly patients with acute pulmonary embolism - Hofmann, E.; Limacher, A.; Mean, M.; Kucher, N.; Righini, M.; Frauchiger, B.; Beer, J. H.; Osterwalder, J.; Aschwanden, M.; Matter, C. M.; Banyai, M.; Egloff, M.; et al. (Thromb Res, 2016)
BACKGROUND: The evidence on the prognostic value of transthoracic echocardiography (TTE) in elderly, hemodynamically stable patients with Pulmonary Embolism (PE) is limited. OBJECTIVES: To evaluate the prevalence of common echocardiographic signs of right ventricular (RV) dysfunction and their prognostic impact in hemodynamically stable patients aged >/=65years with acute PE in a prospective multicenter cohort. METHODS: TTE was performed by cardiologists. We defined RV dysfunction as a RV/left ventricular ratio >0.9 or RV hypokinesis (primary definition) or the presence of >/=1 or >/=2 of 6 predefined echocardiographic signs (secondary definitions). Outcomes were overall mortality and mortality/non-fatal recurrent venous thromboembolism (VTE) at 30days, adjusting for the Pulmonary Embolism Severity Index risk score and highly sensitive troponin T values. RESULTS: Of 400 patients, 36% had RV dysfunction based on our primary definition, and 81% (>/=1 sign) and 53% (>/=2 signs) based on our secondary definitions, respectively. Using our primary definition, there was no association between RV dysfunction and mortality (adjusted HR 0.90, 95% CI 0.31-2.58) and mortality/non-fatal VTE (adjusted HR 1.09, 95% CI 0.40-2.98). Similarly, there was no statistically significant association between the presence of >/=1 or >/=2 echocardiographic signs (secondary definitions) and clinical outcomes. CONCLUSION: The prevalence of echocardiographic RV dysfunction varied widely depending upon the definition used. There was no association between RV dysfunction and clinical outcomes. Thus, TTE may not be suitable as a stand-alone risk assessment tool in elderly patients with acute PE. CLINICAL TRIAL REGISTRATION: http://clinicaltrials.gov. Identifier: NCT00973596.
Keywords: journalArticle; Aged; Aged, 80 and over; Cohort Studies; Echocardiography; Echocardiography/*methods; Female; Humans; Male; Mortality; Prospective Studies; Pulmonary Embolism/*diagnostic imaging/mortality; Pulmonary embolism; Treatment Outcome