European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials - Vermunt, L.; Veal, C. D.; Ter Meulen, L.; Chrysostomou, C.; van der Flier, W.; Frisoni, G. B.; Guessous, I.; Kivipelto, M.; Marizzoni, M.; Martinez-Lage, P.; Molinuevo, J. L.; Porteous, D.; et al. (Alzheimers Dement, 2018)
INTRODUCTION: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. METHODS: A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. RESULTS: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. DISCUSSION: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.
Keywords: journalArticle; *Clinical Trials as Topic; *Patient Selection; *Registries; Aged; Aged, 80 and over; Alzheimer Disease/*prevention & control; Biomarkers; Clinical trial; Epad; Europe; Female; Humans; Longitudinal Studies; Male; Middle Aged; Participant recruitment; Preclinical AD; Prodromal AD; Prodromal Symptoms; Research registry; Risk Factors