Lung Assessment with Point-of-Care Ultrasound in Respiratory Coronavirus Disease (COVID-19): A Prospective Cohort Study - Speidel, V.; Conen, A.; Gisler, V.; Fux, C. A.; Haubitz, S. (Ultrasound Med Biol, 2021)
Lung ultrasound (LUS) has shown promising diagnostic potential in different pulmonary conditions. We evaluated the diagnostic accuracy of LUS for pulmonary COVID-19. In this prospective cohort study at a Swiss tertiary care center, patients hospitalized with suspected COVID-19 were scanned using a 12-zone protocol. Association of a summation score (0-36 points) with the final diagnosis was tested using the area under the receiver operating characteristic curve and sensitivity and specificity at different cutoff points. Of the 49 participants, 11 (22%) were later diagnosed with COVID-19. LUS score showed excellent diagnostic performance, with an odds ratio of 1.30 per point (95% confidence interval [CI], 1.09-1.54, p = 0.003) and an area under the curve of 0.85 (95% CI, 0.71-0.99). At a cutoff of 8/36 points, 10 of 11 participants later diagnosed with COVID-19 were correctly predicted (sensitivity 91%, 95% CI, 59%-100%), and 29 of the 38 who were not diagnosed with COVID-19 were correctly ruled out (specificity 76%, 95% CI, 60%-89%). LUS demonstrated promising discriminatory potential in people hospitalized with suspected COVID-19.
Keywords: journalArticle; *Point-of-Care Systems; Adult; Aged; Aged, 80 and over; COVID-19/*diagnostic imaging; Cohort Studies; Coronavirus disease; Covid-19; Female; Humans; Interstitial syndrome; Lung ultrasound; Lung/*diagnostic imaging; Male; Middle Aged; Pleura ultrasound; Pneumonia; Point of care ultrasound; Prospective Studies; Reproducibility of Results; SARS-CoV-2; Sensitivity and Specificity; Ultrasonography/*methods