Myoglobin for Detection of High-Risk Patients with Acute Myocarditis - Kottwitz, J.; Bruno, K. A.; Berg, J.; Salomon, G. R.; Fairweather, D.; Elhassan, M.; Baltensperger, N.; Kissel, C. K.; Lovrinovic, M.; Baltensweiler, A.; Schmied, C.; Templin, C.; et al. (J Cardiovasc Transl Res, 2020)
There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (r(s) = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (r(s) = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin >/= 87 mug/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. Graphical Abstract Receiver operating curve analysis determined myoglobin >/= 87 mug/L as cutoff to identify myocarditis and these data were reproduced in an established model of coxsackievirus B3 myocarditis in mice: CMRI, cardiac magnetic resonance imaging; Mb, myoglobin; LGE, late gadolinium enhancement; ROC, receiver operating curve analysis.
Keywords: journalArticle; (Circulation. 2018; *Magnetic Resonance Imaging, Cine; 136[suppl; 138[suppl I]:A12867).; Acute Disease; Adult; Animals; Association in Chicago, IL, November 5, 2018, and published as an abstract; Biomarker; Biomarkers/blood; CA, November 14, 2017, and published as an abstract (Circulation.2017; Cardiac enzymes; Contrast Media/*administration & dosage; Coxsackievirus Infections/blood/diagnostic imaging/virology; Disease Models, Animal; Female; Humans; I]: A15156). Further data of this work were presented in part for the Paul Dudley; Late gadolinium enhancement; Magnetic resonance imaging; Male; Mice, Inbred BALB C; Middle Aged; Myocardial inflammation; Myocarditis; Myocarditis/*blood/*diagnostic imaging/virology; Myoglobin; Myoglobin/*blood; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Troponin; White International Scholar Award at the meeting of the American Heart; presented in part at the meeting of the American Heart Association in Anaheim,